Psoriasis causes pubmed. Psoriasis affects approximately 2% of the population worldwide, and dramatic advances have been achieved … Psoriasis is an immune-mediated inflammatory skin disease, involving a complex interplay between genetic and environmental factors. The classic skin lesions can be described as sharply demarcated, scaly, erythematous plaques often found on the extensor surfaces. (A) Psoriasis vulgaris characteristically shows acanthosis, parakeratosis, and dermal inflammatory infiltrates. Several variants of psoriasis have also been described, PubMed® comprises more than 39 million citations for biomedical literature from MEDLINE, life science journals, and online books. In this Primer The prevalence in children is generally lower than in adults (Sandoval, Pierce & Feldman, 2014). (B) In pustular psoriasis, acanthotic changes are accompanied by epidermal predominantly neutrophilic infiltrates, which cause pustule formation. Sep 5, 2015 · Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. Genetic factors play a significant role in the pathogenesis of psoriasis. 1. The psychosocial impact of psoriasis on patients and their coping mechanisms is also explored. Jun 17, 2025 · Psoriasis is a chronic inflammatory skin disease with a complex clinical picture that remains incurable and requires ongoing dermatological care. 2. . Sep 8, 2025 · Psoriasis is a chronic, immune-mediated inflammatory skin disorder affecting approximately 100 million people worldwide (GBD 2019 IMID Collaborators, 2023; Griffiths et al, 2021). The cornerstone of psoriasis Jun 26, 2025 · Psoriasis is a chronic inflammatory disease characterized by cutaneous manifestations, which can also have systemic effects on joints, the cardiovascular system and metabolism. Main Cytokines and Cell Types in Plaque Psoriasis Disturbances in the innate and adaptive cutaneous Apr 29, 2025 · This review provides a comprehensive overview of the current knowledge on psoriasis, covering its definition, prevalence, causes, pathogenesis, clinical features, diagnosis, and treatment options. Psoriasis provides many challenges including high prevalence, chronicity, disfiguration, disability, and associated … Psoriasis is one of the most frequent chronic inflammatory skin diseases. Topical therapies remain the cornerstone for treating mild psoriasis. A diverse team of clinicians with a range of expertise is often needed to treat the disease. Causes and risk factors The exact cause of psoriasis is not fully understood, but research recommends that it is likely a combination of environmental and genetic factors. The prevalence of psoriasis varies with the country, and psoriasis can appear at any age [3, 4], suggesting that ethnicity, genetic background, and environmental factors affect the onset of psoriasis. Histopathology of psoriasis. Therapeutic advancements for moderate to severe plaque psoriasis include biologics th … Psoriasis is a complex chronic inflammatory skin disease caused by the dynamic interplay between multiple genetic risk foci, environmental risk factors, and excessive immunological abnormalities. The National Psoriasis Foundation is here to help you get the treatment you need while promoting research to find a cure for psoriasis and psoriatic arthritis. The purpose of this literature review is to identify the latest therapeutic strategies used to treat psoriasis, taking into account both the efficacy of modern approaches and their impact on patients’ quality of life. However, Psoriasis is a chronic, common, inflammatory skin disease. Previous studies have demonstrated that genetic factors play a major role in the pathogenesis of psoriasis. Citations may include links to full text content from PubMed Central and publisher web sites. It is characterized by the rapid proliferation of keratinocytes leading to the formation of scaly, erythematous plaques, which cause significant physical discomfort and have profound psychological and social impacts May 19, 2020 · Psoriasis is an inflammatory skin disease that is associated with multiple comorbidities and substantially diminishes patients' quality of life. bqha cimugy gdtuqc gydr xpwpoct ibpzdgt zlejrr xkhn qsh toggxo